منابع مشابه
Synthetic oligonucleotides as therapeutic agents.
Currently there is much excitement in certain quarters about antisense oligonucleotides, both as the drugs of the future for treatment of cancer and viral infections, most notably AIDS, and also as genetic tools for generating mutant phenocopies without genomic mutation in investigations of mammalian gene function. The extent of this excitement is reflected in the proliferation of antisense bio...
متن کاملAntisense oligonucleotides as therapeutic agents--is the bullet really magical?
Because of the specificity of Watson-Crick base pairing, attempts are now being made to use oligodeoxynucleotides (oligos) in the therapy of human disease. However, for a successful outcome, the oligo must meet at least six criteria: (i) the oligos can be synthesized easily and in bulk; (ii) the oligos must be stable in vivo; (iii) the oligos must be able to enter the target cell; (iv) the olig...
متن کاملSplice-switching antisense oligonucleotides as therapeutic drugs
Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA-RNA base-pairing or protein-RNA binding interactions that occur between components of the splicing machinery and the pre-mRNA. Splicing of pre-mRNA is required for the proper expression of...
متن کاملMushrooms as therapeutic agents
Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of in...
متن کاملViruses as Therapeutic Agents
A relatively noncytopathic virus, lymphocytic choriomeningitis virus (LCMV),1 prevents the development of insulin-dependent diabetes mellitus (IDDM) in nonobese insulin-dependent diabetes (NOD) mice (1, 2). Typically, >90% of NOD female mice, by 9 mo of age, develop hyperglycemia, hypoinsulinemia, and lymphocytic infiltrates in the islets of Langerhans, with a cell destruction . However, their ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1998
ISSN: 1468-6244
DOI: 10.1136/jmg.35.8.703-a